Article

Conditional frequency spectra as a tool for studying selection on complex traits in biobanks

2024-06-17

Abstract excerpt

Natural selection on complex traits is difficult to study in part due to the ascertainment inherent to genome-wide association studies (GWAS). The power to detect a trait-associated variant in GWAS is a function of frequency and effect size — but for traits under selection, the effect size of a variant determines the strength of selection against it, constraining its frequency. To account for GWAS ascertainment, w...

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Literature Corpus work: d0261407-3b33-5830-823e-ba3f246dd0ec
DOI: 10.1101/2024.06.15.599126

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