Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterizing selection on complex traits through conditional frequency spectra.

Genetics - 17 Apr 2025

Patel Roshni A, Weiß Clemens L, Zhu Huisheng, Mostafavi Hakhamanesh, Simons Yuval B, Spence Jeffrey P, Pritchard Jonathan K

Abstract excerpt

Natural selection on complex traits is difficult to study in part due to the ascertainment inherent to genome-wide association studies (GWAS). The power to detect a trait-associated variant in GWAS is a function of its frequency and effect size - but for traits under selection, the effect size of a variant determines the strength of selection against it, constraining its frequency. Recognizing the biases inherent...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Frequency
Share to Genetic Variation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome-Wide Association Study

Share to Models, Genetic

Share to Probability

Share to Selection, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 39691067
DOI: 10.1093/genetics/iyae210
PMCID: PMC12005249

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterizing selection on complex traits through conditional frequency spectra.PMID 39691067Read ↗

Conditional frequency spectra as a tool for studying selection on complex traits in biobanksSemantic proximity Read ↗

Leveraging GWAS for complex traits to detect signatures of natural selection in humans.Semantic proximity Read ↗

Determining the driving factors shaping genetic architecture of complex traits in recently admixed populationsSemantic proximity Read ↗

Selection and explosive growth may hamper the performance of rare variant association testsSemantic proximity Read ↗

Genetic association data are broadly consistent with stabilizing selection shaping human common diseases and traitsSemantic proximity Read ↗

Simple scaling laws control the genetic architectures of human complex traitsSemantic proximity Read ↗

Widespread signatures of negative selection in the genetic architecture of human complex traitsSemantic proximity Read ↗

A population genetic interpretation of GWAS findings for human quantitative traits.Semantic proximity Read ↗

Mosaic patterns of selection in genomic regions associated with diverse human traitsSemantic proximity Read ↗

Mutation-selection-drift balance models of complex diseasesSemantic proximity Read ↗

Widespread signatures of natural selection across human complex traits and functional genomic categories.Semantic proximity Read ↗

Polygenicity of complex traits is explained by negative selectionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.