Article

Heterozygosity for Crohn’s Disease Risk Allele of <i>ATG16L1</i> Protects against Bacterial Infection

2024-02-25

Abstract excerpt

The T300A substitution in ATG16L1 associated with Crohn’s Disease impairs autophagy, yet up to 50% of humans are heterozygous for this allele. Here we demonstrate that heterozygosity for the analogous substitution in mice ( Atg16L1 T316A ), but not homozygosity, protects against lethal Salmonella enterica Typhimurium infection. One copy of Atg16L1 T316A was sufficient to enhance cytokine production through in...

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Literature Corpus work: d01f8ca4-50a1-517c-8dd5-70d7fba487fe
DOI: 10.1101/2024.02.22.581423

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