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Article

Unconventional autophagy mediated by the WD40 domain of ATG16L1 is derailed by the T300A Crohn disease risk polymorphism.

Autophagy - 1 Nov 2016

Serramito-Gómez Inmaculada, Boada-Romero Emilio, Pimentel-Muiños Felipe X

Abstract excerpt

A coding polymorphism of the critical autophagic effector ATG16L1 (T300A) increases the risk of Crohn disease, but how this mutation influences the function of ATG16L1 has remained unclear. In a recent report, we showed that the A300 allele alters the ability of the C-terminal WD40 domain of ATG16L1 to interact with proteins containing a specific amino acid motif able to recognize this region. This defect impairs...

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Source

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Identifiers

PMID: 27541200
DOI: 10.1080/15548627.2016.1216303
PMCID: PMC5103359

Genes

TMEM59

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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