Article
An alteration in ATG16L1 stability in Crohn disease.
Autophagy - 1 Oct 2014
Lassen Kara G, Xavier Ramnik J
Abstract excerpt
Individuals who harbor a common coding polymorphism (Thr300Ala) within a structurally unclassified region of ATG16L1 are at increased risk for the development of Crohn disease. Recently, we reported on the generation and characterization of knockin mice carrying the ATG16L1 T300A variant. We demonstrate that multiple cell types from T300A knock-in mice exhibit reduced selective autophagy, and we mechanistically...
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