Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Heterozygosity for Crohn's disease risk allele of ATG16L1 promotes unique protein interactions and protects against bacterial infection.

Immunity - 10 Jun 2025

Yao Xiaomin, Rudensky Eugene, Martin Patricia K, Miller Brittany M, Vargas Isabel, Zwack Erin E, Lacey Keenan A, He Zhengxiang, Furtado Glaucia C, Lira Sérgio A, Torres Victor J, Shopsin Bo, Cadwell Ken

Abstract excerpt

The T300A substitution in ATG16L1 associated with Crohn's disease impairs autophagy, yet up to 50% of humans are heterozygous for this allele. Here, we demonstrate that heterozygosity for the analogous substitution in mice (Atg16L1T316A), but not homozygosity, protects against lethal Salmonella enterica Typhimurium infection. One copy of Atg16L1T316A was sufficient to enhance cytokine production through...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy
Share to Autophagy-Related Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Crohn Disease

Share to Inflammasomes

Share to Macrophages

Share to Phagocytosis

Share to Salmonella Infections

Share to Salmonella typhimurium

Source

Open in PubMed Open full text

Identifiers

PMID: 40373771
DOI: 10.1016/j.immuni.2025.04.023
PMCID: PMC12158642

Genes

ATG16L1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Heterozygosity for Crohn's disease risk allele of ATG16L1 promotes unique protein interactions and protects against bacterial infection.PMID 40373771Read ↗

Heterozygosity for Crohn’s Disease Risk Allele of <i>ATG16L1</i> Protects against Bacterial InfectionSemantic proximity Read ↗

ATG16L1: A multifunctional susceptibility factor in Crohn disease.Semantic proximity Read ↗

Impaired autophagy of an intracellular pathogen induced by a Crohn's disease associated ATG16L1 variant.Semantic proximity Read ↗

The T300A Crohn's disease risk polymorphism impairs function of the WD40 domain of ATG16L1.Semantic proximity Read ↗

Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense.Semantic proximity Read ↗

The Inflammatory Bowel Disease-Associated Autophagy Gene Atg16L1T300A Acts as a Dominant Negative Variant in Mice.Semantic proximity Read ↗

Unconventional autophagy mediated by the WD40 domain of ATG16L1 is derailed by the T300A Crohn disease risk polymorphism.Semantic proximity Read ↗

A Crohn's disease variant in Atg16l1 enhances its degradation by caspase 3.Semantic proximity Read ↗

The Crohn Disease-associated ATG16L1<sup>T300A</sup> polymorphism regulates inflammatory responses by modulating TLR- and NLR-mediated signalingSemantic proximity Read ↗

An alteration in ATG16L1 stability in Crohn disease.Semantic proximity Read ↗

Alterations of autophagic and innate immune responses by the Crohn's disease-associated ATG16L1 mutation.Semantic proximity Read ↗

Balancing immunity: disease risk mutation can be beneficial.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.