A Crohn's disease variant in Atg16l1 enhances its degradation by caspase 3.

doi:10.1038/nature13044

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

A Crohn's disease variant in Atg16l1 enhances its degradation by caspase 3.

Nature - 27 Feb 2014

Murthy Aditya, Li Yun, Peng Ivan, Reichelt Mike, Katakam Anand Kumar, Noubade Rajkumar, Roose-Girma Merone, DeVoss Jason, Diehl Lauri, Graham Robert R, van Lookeren Campagne Menno

Abstract excerpt

Crohn's disease is a debilitating inflammatory bowel disease (IBD) that can involve the entire digestive tract. A single-nucleotide polymorphism (SNP) encoding a missense variant in the autophagy gene ATG16L1 (rs2241880, Thr300Ala) is strongly associated with the incidence of Crohn's disease. Numerous studies have demonstrated the effect of ATG16L1 deletion or deficiency; however, the molecular consequences of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Motifs

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Autophagy

Share to Autophagy-Related Proteins

Share to Caspase 3

Share to Crohn Disease

Share to Food Deprivation

Share to Proteolysis

Share to Yersinia enterocolitica

Source

Open in PubMed

Identifiers

PMID: 24553140
DOI: 10.1038/nature13044

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Crohn's disease variant in Atg16l1 enhances its degradation by caspase 3.PMID 24553140Read ↗

Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense.Semantic proximity Read ↗

An alteration in ATG16L1 stability in Crohn disease.Semantic proximity Read ↗

The T300A Crohn's disease risk polymorphism impairs function of the WD40 domain of ATG16L1.Semantic proximity Read ↗

The Crohn Disease-associated ATG16L1<sup>T300A</sup> polymorphism regulates inflammatory responses by modulating TLR- and NLR-mediated signalingSemantic proximity Read ↗

ATG16L1: A multifunctional susceptibility factor in Crohn disease.Semantic proximity Read ↗

Impaired autophagy of an intracellular pathogen induced by a Crohn's disease associated ATG16L1 variant.Semantic proximity Read ↗

The Inflammatory Bowel Disease-Associated Autophagy Gene Atg16L1T300A Acts as a Dominant Negative Variant in Mice.Semantic proximity Read ↗

Heterozygosity for Crohn's disease risk allele of ATG16L1 promotes unique protein interactions and protects against bacterial infection.Semantic proximity Read ↗

Alterations of autophagic and innate immune responses by the Crohn's disease-associated ATG16L1 mutation.Semantic proximity Read ↗

A nonsynonymous SNP in ATG16L1 predisposes to ileal Crohn's disease and is independent of CARD15 and IBD5.Semantic proximity Read ↗

Heterozygosity for Crohn’s Disease Risk Allele of <i>ATG16L1</i> Protects against Bacterial InfectionSemantic proximity Read ↗

Functional consequences of mutations in the autophagy genes in the pathogenesis of Crohn's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.