Article
The Inflammatory Bowel Disease-Associated Autophagy Gene Atg16L1T300A Acts as a Dominant Negative Variant in Mice.
Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 2017
Gao Ping, Liu Hongtao, Huang Huarong, Zhang Qi, Strober Warren, Zhang Fuping
Abstract excerpt
The basis of the increased risk for Crohn's disease conferred by the Atg16L1T300A polymorphism is incompletely understood. An important step forward came from the recent demonstration that the murine equivalent of Atg16L1T300A (Atg16L1T316A) exhibits increased susceptibility to caspase 3-mediated cleavage and resulting decreased levels of full-length Atg16L1 in macrophages. However, although this finding showed...
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