Article
The Crohn Disease-associated ATG16L1<sup>T300A</sup> polymorphism regulates inflammatory responses by modulating TLR- and NLR-mediated signaling
27 Feb 2022
Abstract excerpt
The mechanisms by which the ATG16L1T300A polymorphism affects cell function and causes an increased risk for the development of Crohn disease remain incompletely understood. Here we report that healthy individuals and mice bearing this polymorphism, even as heterozygotes, manifest enhanced TLR, and NLR cytokine and chemokine responses due to increased activation of NFKB. We elucidated the mechanism of the NFKB...
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