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Uncoupling interferons and the interferon signature explain clinical and transcriptional subsets in SLE

2023-08-28

Abstract excerpt

<h4>Summary</h4> Interferons (IFN) are thought to be key players in systemic lupus erythematosus (SLE). The unique and interactive roles of the different IFN families in SLE pathogenesis, however, remain poorly understood. Using reporter cells engineered to precisely quantify IFN-I, IFN-II and IFN-III activity levels in serum/plasma, we found that while IFNs play essential role in SLE pathogenesis and disease acti...

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Literature Corpus work
d0067c12-f2b3-5bcf-a537-af94d1aacc65
DOI
10.1101/2023.08.28.23294734
Open publication

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Uncoupling interferons and the interferon signature explain clinical and transcriptional subsets in SLEDOI 10.1101/2023.08.28.23294734
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