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Expression signatures with specificity for type I and II IFN response and relevance for autoimmune diseases and cancer

3 Jul 2025

Abstract excerpt

Abstract Background Aberrant interferon signaling is a key element of various diseases, but resolving gene expression signatures that stem from different types of IFNs in tissue samples is still a challenge. Most published IFN signatures comprise genes that are activated by different IFNs: they cannot discriminate type-I (IFN-I) and type-II (IFN-II) IFN stimulation. Most often such signatures were obtained from a...

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PMID: 40611262
DOI: 10.1186/s12967-025-06628-7

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