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Article

Interferon pathway in SLE: one key to unlocking the mystery of the disease

1 Aug 2019

Abstract excerpt

SLE is characterised by an activation of the interferon (IFN) system, which leads to an increased expression of IFN-regulated genes. The reasons behind the IFN signature in SLE are (1) the existence of endogenous IFN inducers, (2) activation of several IFN-producing cell types, (3) production of many different IFNs, (4) a genetic setup promoting IFN production and (5) deficient negative feedback mechanisms. The...

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PMID: 31497305
DOI: 10.1136/lupus-2018-000270

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