Article
The interferon signature in autoimmune diseases.
Current opinion in rheumatology - 1 Mar 2013
Rönnblom Lars, Eloranta Maija-Leena
Abstract excerpt
PURPOSE OF REVIEW: An increased expression of type I interferon (IFN) regulated genes (an IFN signature) has been reported in blood and tissue cells from patients with SLE and other autoimmune diseases. We review the possible mechanisms behind the IFN signature as well as clinical and therapeutic consequences of this observation. RECENT FINDINGS: Autoantigens from dying cells trigger plasmacytoid dendritic cells...
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