Article

Genetic mechanisms for impaired synaptic plasticity in schizophrenia revealed by computational modelling

2023-06-14

Abstract excerpt

Schizophrenia phenotypes are suggestive of impaired cortical plasticity in the disease, but the mechanisms of these deficits are unknown. Genomic association studies have implicated a large number of genes that regulate neuromodulation and plasticity, indicating that the plasticity deficits have a genetic origin. Here, we used biochemically detailed computational modelling of post-synaptic plasticity to investigat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d00488cc-6a45-5aac-a594-baa55be9dfd0
DOI: 10.1101/2023.06.14.544920

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genetic mechanisms for impaired synaptic plasticity in schizophrenia revealed by computational modellingDOI 10.1101/2023.06.14.544920Read

Computational modelling of schizophrenia-associated alterations of ion-channel-encoding gene expression predicts a decrease in delta powerSemantic proximity Read

Genetic risk for schizophrenia: convergence on synaptic pathways involved in plasticity.Semantic proximity Read

A Transcriptome Wide Association Study implicates specific pre- and post-synaptic abnormalities in SchizophreniaSemantic proximity Read

Novel treatment strategies for schizophrenia from improved understanding of genetic risk.Semantic proximity Read

A network of synaptic genes associated with schizophrenia and bipolar disorder.Semantic proximity Read

A computational framework linking molecular regulation, synaptic plasticity, and brain disordersSemantic proximity Read

Schizophrenia Genomics: Convergence on Synaptic Development, Adult Synaptic Plasticity, or Both?Semantic proximity Read

Genetic evidence for role of integration of fast and slow neurotransmission in schizophrenia.Semantic proximity Read

Comprehensive pathway analyses of schizophrenia risk loci point to dysfunctional postsynaptic signalingSemantic proximity Read

Decoding Advances in Psychiatric Genetics: A Focus on Neural Circuits in Rodent Models.Semantic proximity Read

Schizophrenia-associated SAP97 mutations increase glutamatergic synapse strength in the dentate gyrus and impair contextual episodic memory in rats.Semantic proximity Read

Comprehensive analysis of schizophrenia-associated loci highlights ion channel pathways and biologically plausible candidate causal genes.Semantic proximity Read