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Article

Schizophrenia-associated SAP97 mutations increase glutamatergic synapse strength in the dentate gyrus and impair contextual episodic memory in rats.

Nature communications - 10 Feb 2022

Kay Yuni, Tsan Linda, Davis Elizabeth A, Tian Chen, Décarie-Spain Léa, Sadybekov Anastasiia, Pushkin Anna N, Katritch Vsevolod, Kanoski Scott E, Herring Bruce E

Abstract excerpt

Mutations in the putative glutamatergic synapse scaffolding protein SAP97 are associated with the development of schizophrenia in humans. However, the role of SAP97 in synaptic regulation is unclear. Here we show that SAP97 is expressed in the dendrites of granule neurons in the dentate gyrus but not in the dendrites of other hippocampal neurons. Schizophrenia-related perturbations of SAP97 did not affect CA1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35145085
DOI: 10.1038/s41467-022-28430-5
PMCID: PMC8831576

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