Article

Comprehensive pathway analyses of schizophrenia risk loci point to dysfunctional postsynaptic signaling

2017-03-17

Abstract excerpt

Large-scale genome-wide association studies (GWAS) have implicated many low-penetrance loci in schizophrenia. However, its pathological mechanisms are poorly understood, which in turn hampers the development of novel pharmacological treatments. Pathway and gene set analyses carry the potential to generate hypotheses about disease mechanisms and have provided biological context to genome-wide data of schizophrenia....

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Literature Corpus work: f8ab3162-5cbc-52cd-b2a1-77fe109fd118
DOI: 10.1101/117481

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