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Article

Comprehensive analysis of schizophrenia-associated loci highlights ion channel pathways and biologically plausible candidate causal genes.

Human molecular genetics - 15 Mar 2016

Pers Tune H, Timshel Pascal, Ripke Stephan, Lent Samantha, Sullivan Patrick F, O'Donovan Michael C, Franke Lude, Hirschhorn Joel N

Abstract excerpt

Over 100 associated genetic loci have been robustly associated with schizophrenia. Gene prioritization and pathway analysis have focused on a priori hypotheses and thus may have been unduly influenced by prior assumptions and missed important causal genes and pathways. Using a data-driven approach, we show that genes in associated loci: (1) are highly expressed in cortical brain areas; (2) are enriched for ion...

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Source

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Identifiers

PMID: 26755824
DOI: 10.1093/hmg/ddw007
PMCID: PMC4764200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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