Article

Evidence linking APOBEC3B genesis and evolution of innate immune antagonism by gamma-herpesvirus ribonucleotide reductases

2022-04-04

Abstract excerpt

Viruses have evolved diverse mechanisms to antagonize host immunity such as direct inhibition and relocalization of cellular APOBEC3B (A3B) by the ribonucleotide reductase (RNR) of Epstein-Barr virus. Here, we investigate the mechanistic conservation and evolutionary origin of this innate immune counteraction strategy. First, we find that human gamma-herpesvirus RNRs engage A3B via largely distinct surfaces. Secon...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d003e4ce-2091-515d-988d-e13d3898d20b
DOI: 10.1101/2022.04.04.487025

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Evidence linking APOBEC3B genesis and evolution of innate immune antagonism by gamma-herpesvirus ribonucleotide reductasesDOI 10.1101/2022.04.04.487025Read

Evidence linking APOBEC3B genesis and evolution of innate immune antagonism by gamma-herpesvirus ribonucleotide reductasesSemantic proximity Read

APOBECs and HerpesvirusesSemantic proximity Read

Ancient adaptive evolution of the primate antiviral DNA-editing enzyme APOBEC3G.Semantic proximity Read

The role of cytidine deaminases on innate immune responses against human viral infections.Semantic proximity Read

The APOBEC3 Cytidine Deaminases: An Innate Defensive Network Opposing Exogenous Retroviruses and Endogenous RetroelementsSemantic proximity Read

Role of the single deaminase domain APOBEC3A in virus restriction, retrotransposition, DNA damage and cancerSemantic proximity Read

APOBEC3 Interference during Replication of Viral Genomes.Semantic proximity Read

Cytidine Deaminases as a Weapon Against Retroviruses and a New Target for Antiviral TherapySemantic proximity Read

Evolutionary effects of the AID/APOBEC family of mutagenic enzymes on human gamma-herpesvirusesSemantic proximity Read

Adaptive evolution and antiviral activity of the conserved mammalian cytidine deaminase APOBEC3H.Semantic proximity Read

Antiviral Mechanism and Biochemical Basis of the Human APOBEC3 FamilySemantic proximity Read

A conflict of interest: the evolutionary arms race between mammalian APOBEC3 and lentiviral VifSemantic proximity Read