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A conflict of interest: the evolutionary arms race between mammalian APOBEC3 and lentiviral Vif

8 May 2017

Abstract excerpt

Apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3 (APOBEC3) proteins are mammalian-specific cellular deaminases and have a robust ability to restrain lentivirus replication. To antagonize APOBEC3-mediated antiviral action, lentiviruses have acquired viral infectivity factor (Vif) as an accessory gene. Mammalian APOBEC3 proteins inhibit lentiviral replication by enzymatically inserting G-to-A...

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PMID: 28482907
DOI: 10.1186/s12977-017-0355-4

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