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Cytidine Deaminases as a Weapon Against Retroviruses and a New Target for Antiviral Therapy

1 Mar 2008

Abstract excerpt

APOBEC3G (apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3G) was identified as an anti-HIV-1 (human immunodeficiency virus type 1) cellular factor in target CD4 T cells. It is a member of the APOBEC family of cytidine deaminases consisting of APOBEC1, APOBEC2, APOBEC3 (A to H), and AID (activation induced deaminase). During reverse transcription, it deaminates dC to dU in nascent minus-strand...

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PMID: 18336343
DOI: 10.2174/138955708783744047

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