Article

One-shot identification of SARS-CoV-2 S RBD escape mutants using yeast screening

2021-03-15

Abstract excerpt

<h4>ABSTRACT</h4> The potential emergence of SARS-CoV-2 Spike (S) escape mutants is a threat to reduce the efficacy of existing vaccines and neutralizing antibody (nAb) therapies. An understanding of the antibody/S escape mutations landscape is urgently needed to preemptively address this threat. Here we describe a rapid method to identify escape mutants for nAbs targeting the S receptor binding site. We identifi...

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Literature Corpus work: e3fe4b59-54ae-5038-8731-26086fa621d0
DOI: 10.1101/2021.03.15.435309

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