Intricate mechanism (s) of substrate specificity and loss of function on disease mutation (K211N) of Parkin

Abstract excerpt

Parkin mutations lead to the early onset of Parkinson’s disease. PINK1-mediated phosphorylation of its substrates Ubiquitin (Ub)-like proteins (NEDD8, Ubiquitin) and Ubiquitin-like (Ubl) domain activate autoinhibited Parkin. Substrate specificity on Parkin and the cause of loss of function in disease mutation K211N remain elusive. Herein, we determine the first crystal structure of human Parkin bound with phospho(...

Topics

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• Allosteric Regulation
• Catalytic Domain
• Crystallography, X-Ray
• Parkinson Disease
• Protein Conformation
• Protein Kinases
• Ubiquitin
• Ubiquitin-Protein Ligases

Identifiers and source

Literature Corpus work

387efd2d-315a-5ebf-8a3e-d0a4e316fcb6

DOI

10.1101/2023.11.21.568018