Article

Mechanism of Ubiquitin Ligase Activation of Parkin by a Small Molecule Molecular Glue

2024-03-19

Abstract excerpt

<title>Abstract</title> <p>Mutations in parkin and PINK1 cause early-onset Parkinson’s disease (EOPD). The ubiquitin ligase parkin is recruited to damaged mitochondria and activated by PINK1, a kinase that phosphorylates ubiquitin and the ubiquitin-like (Ubl) domain of parkin. Activated phospho-parkin then ubiquitinates mitochondrial proteins to target the damaged organelle for degradation. Here, we present the m...

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Literature Corpus work: 0e811523-6758-57fc-92b2-87b6d5b0a0bc
DOI: 10.21203/rs.3.rs-4119143/v1

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