Article

Genome-wide association study and functional validation implicates JADE1 in tauopathy

2021-07-01

Abstract excerpt

Primary age-related tauopathy (PART) is a neurodegenerative tauopathy with features distinct from but also overlapping with Alzheimer disease (AD). While both exhibit Alzheimer-type temporal lobe neurofibrillary degeneration alongside amnestic cognitive impairment, PART develops independently of amyloid-β (Aβ) deposition in plaques. The pathogenesis of PART is unknown, but evidence suggests it is associated with g...

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Literature Corpus work: 28a8be08-f561-593c-b007-7ef3f23ebd69
DOI: 10.1101/2021.06.30.450599

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