Article
Genome-wide association study and functional validation implicates JADE1 in tauopathy.
Acta neuropathologica - 1 Jan 2022
Farrell Kurt, Kim SoongHo, Han Natalia, Iida Megan A, Gonzalez Elias M, Otero-Garcia Marcos, Walker Jamie M, Richardson Timothy E, Renton Alan E, Andrews Shea J, Fulton-Howard Brian, Humphrey Jack, Vialle Ricardo A, Bowles Kathryn R, de Paiva Lopes Katia, Whitney Kristen, Dangoor Diana K, Walsh Hadley, Marcora Edoardo, Hefti Marco M, Casella Alicia, Sissoko Cheick T, Kapoor Manav, Novikova Gloriia, Udine Evan, Wong Garrett, Tang Weijing, Bhangale Tushar, Hunkapiller Julie, Ayalon Gai, Graham Robert R, Cherry Jonathan D, Cortes Etty P, Borukov Valeriy Y, McKee Ann C, Stein Thor D, Vonsattel Jean-Paul, Teich Andy F, Gearing Marla, Glass Jonathan, Troncoso Juan C, Frosch Matthew P, Hyman Bradley T, Dickson Dennis W, Murray Melissa E, Attems Johannes, Flanagan Margaret E, Mao Qinwen, Mesulam M-Marsel, Weintraub Sandra, Woltjer Randy L, Pham Thao, Kofler Julia, Schneider Julie A, Yu Lei, Purohit Dushyant P, Haroutunian Vahram, Hof Patrick R, Gandy Sam, Sano Mary, Beach Thomas G, Poon Wayne, Kawas Claudia H, Corrada María M, Rissman Robert A, Metcalf Jeff, Shuldberg Sara, Salehi Bahar, Nelson Peter T, Trojanowski John Q, Lee Edward B, Wolk David A, McMillan Corey T, Keene C Dirk, Latimer Caitlin S, Montine Thomas J, Kovacs Gabor G, Lutz Mirjam I, Fischer Peter, Perrin Richard J, Cairns Nigel J, Franklin Erin E, Cohen Herbert T, Raj Towfique, Cobos Inma, Frost Bess, Goate Alison, White Iii Charles L, Crary John F
Abstract excerpt
Primary age-related tauopathy (PART) is a neurodegenerative pathology with features distinct from but also overlapping with Alzheimer disease (AD). While both exhibit Alzheimer-type temporal lobe neurofibrillary degeneration alongside amnestic cognitive impairment, PART develops independently of amyloid-β (Aβ) plaques. The pathogenesis of PART is not known, but evidence suggests an association with genes that...
Read the complete abstract on PubMed