Article

<i>C. elegans</i> PVD Neurons: A Platform for Functionally Validating and Characterizing Neuropsychiatric Risk Genes

2016-05-17

Abstract excerpt

One of the primary challenges in the field of psychiatric genetics is the lack of an in vivo model system in which to functionally validate candidate n europsychiatric r isk g enes (NRGs) in a rapid and cost-effective manner 1 − 3 . To overcome this obstacle, we performed a candidate-based RNAi screen in which C. elegans orthologs of human NRGs were assayed for dendritic arborization and cell specification d...

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Literature Corpus work: f161f4ce-6f80-5ee6-92bc-5a6623f5d451
DOI: 10.1101/053900

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