Article

Alpha lipoic acid diminishes migration and invasion in hepatocellular carcinoma cells through an AMPK-p53 axis

2023-12-27

Abstract excerpt

<title>Abstract</title> <p>Hepatocellular carcinoma (HCC) associated with viral or metabolic liver diseases is a growing cancer that lacks effective therapy. AMPK is downregulated in the early stages of HCC and its activation diminishes tumor progression in culture and in vivo. Alpha lipoic acid (ALA), an indirect AMPK activator that inhibits hepatic steatosis in rodents, shows antitumor effects in different canc...

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Literature Corpus work: cf4b89b9-b00a-5d53-b501-8bd4b288628a
DOI: 10.21203/rs.3.rs-3773984/v1

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