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Article

AICAR and compound C negatively modulate HCC-induced primary human hepatic stellate cell activation in vitro.

American journal of physiology. Gastrointestinal and liver physiology - 1 Apr 2021

Böttcher Katrin, Longato Lisa, Marrone Giusi, Mazza Giuseppe, Ghemtio Leo, Hall Andrew, Luong Tu Vinh, Caruso Stefano, Viollet Benoit, Zucman-Rossi Jessica, Pinzani Massimo, Rombouts Krista

Abstract excerpt

Tumor stroma and microenvironment have been shown to affect hepatocellular carcinoma (HCC) growth, with activated hepatic stellate cells (HSC) as a major contributor in this process. Recent evidence suggests that the energy sensor adenosine monophosphate-activated kinase (AMPK) may mediate a series of essential processes during carcinogenesis and HCC progression. Here, we investigated the effect of different HCC...

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PMID: 33406006
DOI: 10.1152/ajpgi.00262.2020

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