Article

AMPK deficiency induces DNA methylation and aggravates colorectal tumorigenesis in AOM/DSS mice

2020-05-27

Abstract excerpt

<h4>Background: </h4> The incidence of colorectal cancer (CRC) is closely related to metabolic diseases. AMP-activated protein kinase (AMPK) is known as a key metabolic regulator. Recently, the regulartory function of AMPK in the perspective of cancer metabolic reprogramming have attracted increasingly attention. <h4>Methods:</h4> To assess the regulatory role of AMPK in colonic tumorigenesis, we cross-bred AMPKα1...

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Literature Corpus work: 92421cc1-266b-5a8b-af6e-979cb05c599a
DOI: 10.21203/rs.3.rs-30525/v1

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