Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

AMPK reverses the mesenchymal phenotype of cancer cells by targeting the Akt-MDM2-Foxo3a signaling axis.

Cancer research - 1 Sept 2014

Chou Chih-Chien, Lee Kuen-Haur, Lai I-Lu, Wang Dasheng, Mo Xiaokui, Kulp Samuel K, Shapiro Charles L, Chen Ching-Shih

Abstract excerpt

In cancer cells, the epithelial-mesenchymal transition (EMT) confers the ability to invade basement membranes and metastasize to distant sites, establishing it as an appealing target for therapeutic intervention. Here, we report a novel function of the master metabolic kinase AMPK in suppressing EMT by modulating the Akt-MDM2-Foxo3 signaling axis. This mechanistic link was supported by the effects of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to AMP-Activated Protein Kinases
Share to Cadherins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epithelial-Mesenchymal Transition

Share to Forkhead Box Protein O3

Share to Forkhead Transcription Factors

Share to Prostatic Neoplasms

Share to Proto-Oncogene Proteins c-akt

Share to Proto-Oncogene Proteins c-mdm2

Source

Open in PubMed Open full text

Identifiers

PMID: 24994714
DOI: 10.1158/0008-5472.CAN-14-0135
PMCID: PMC4155002

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

AMPK reverses the mesenchymal phenotype of cancer cells by targeting the Akt-MDM2-Foxo3a signaling axis.PMID 24994714Read ↗

Targeting AMPK for Cancer Therapy: Metabolic Reprogramming as a Therapeutic StrategySemantic proximity Read ↗

The AMPK-FoxO3A axis as a target for cancer treatmentSemantic proximity Read ↗

An integrative pan-cancer investigation reveals common genetic and transcriptional alterations of AMPK pathway genes as important predictors of clinical outcomes across major cancer typesSemantic proximity Read ↗

An integrative pan-cancer investigation reveals common genetic and transcriptional alterations of AMPK pathway genes as important predictors of clinical outcomes across major cancer typesSemantic proximity Read ↗

Elevation of adenylate energy charge by angiopoietin-like 4 enhances epithelial–mesenchymal transition by inducing 14-3-3γ expressionSemantic proximity Read ↗

AMP-activated protein kinase inhibits transforming growth factor-beta-induced Smad3-dependent transcription and myofibroblast transdifferentiation.Semantic proximity Read ↗

Oncogenic MAGEA-TRIM28 ubiquitin ligase downregulates autophagy by ubiquitinating and degrading AMPK in cancerSemantic proximity Read ↗

Energy Homeostasis and Cancer Prevention: The AMP-Activated Protein KinaseSemantic proximity Read ↗

AMPK: An Epigenetic Landscape ModulatorSemantic proximity Read ↗

The Energy Sensor AMP-activated Protein Kinase Directly Regulates the Mammalian FOXO3 Transcription FactorSemantic proximity Read ↗

AMP-activated protein kinase promotes breast cancer stemness and drug resistanceSemantic proximity Read ↗

AMPK downregulates ALK2 via increasing the interaction between Smurf1 and Smad6, leading to inhibition of osteogenic differentiation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.