Activating the AMPK-p53 Axis by Mitochondrial Impairment: Unveiling a Novel Anti-Liver Cancer Mechanism of Sulfane Sulfur

Abstract excerpt

<title>Abstract</title> <p>Hepatocellular carcinoma (HCC) is the most prevalent form of primary liver cancer, notoriously refractory to conventional chemotherapy. Historically, sulfane sulfur-based compounds have been explored for the treatment of HCC, but their efficacy has been underwhelming. We recently reported a novel sulfane sulfur donor, PSCP, which exhibited improved chemical stability and structural mall...

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• Aniline Compounds
• Autophagy in Disease and Therapy
• Cell Line, Tumor
• Curcumin
• Drug Resistance, Neoplasm
• Histone Deacetylase Inhibitors Research
• Lung Neoplasms
• Ubiquitin and proteasome pathways

Identifiers and source

Literature Corpus work

ff07f02e-c52a-5927-9510-22c7b2e5ae2e

DOI

10.21203/rs.3.rs-5228470/v1