Article

Disabling Cas9 by an anti-CRISPR DNA mimic

2017-04-22

Abstract excerpt

CRISPR-Cas9 gene editing technology is derived from a microbial adaptive immune system, where bacteriophages are often the intended target. Natural inhibitors of CRISPR-Cas9 enable phages to evade immunity and show promise in controlling Cas9-mediated gene editing in human cells. However, the mechanism of CRISPR-Cas9 inhibition is not known and the potential applications for Cas9 inhibitor proteins in mammalian ce...

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Literature Corpus work: cf3b154e-d2b0-51ff-a268-e838f20f94ff
DOI: 10.1101/129627

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