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Anti‐CRISPRs: The natural inhibitors for CRISPR‐Cas systems

29 May 2019

Abstract excerpt

CRISPR (clustered regularly interspaced short palindromic repeats)-Cas (CRISPR associated protein) systems serve as the adaptive immune system by which prokaryotes defend themselves against phages. It has also been developed into a series of powerful gene-editing tools. As the natural inhibitors of CRISPR-Cas systems, anti-CRISPRs (Acrs) can be used as the "off-switch" for CRISPR-Cas systems to limit the...

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PMID: 31392299
DOI: 10.1002/ame2.12069

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