Article

Protein language model-guided engineering of an anti-CRISPR protein for precise genome editing in human cells

2023-12-13

Abstract excerpt

Promiscuous editing by CRISPR/Cas systems within the human genome is a major challenge that must be addressed prior to applying these systems therapeutically. In bacteria, CRISPR/Cas systems have evolved in a co-evolutionary arms race with infectious phage viruses that contain inhibitory anti-CRISPR proteins within their genomes. Here, we harness the outcome of this co-evolutionary arms race to engineer an AcrIIA4...

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Literature Corpus work: a3c6eef4-6450-5d90-85a8-d67ec018db79
DOI: 10.1101/2023.12.13.571376

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