Article

Allosteric Inhibition of CRISPR-Cas9 by Bacteriophage-derived Peptides

2019-05-20

Abstract excerpt

<h4>Background</h4> CRISPR-Cas9 has been developed as a therapeutic agent for various infectious and genetic diseases. In many clinically relevant applications, constitutively active CRISPR-Cas9 is delivered into human cells without a temporal control system. Excessive and prolonged expression CRISPR-Cas9 can lead to elevated off-target cleavage. The need for modulating CRISPR-Cas9 activity over the dimensions of...

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Literature Corpus work: 4bb1d317-7f81-51cc-849e-5fb2ed41c101
DOI: 10.1101/642538

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