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Article

Intrinsic disorder is essential for Cas9 inhibition of anti-CRISPR AcrIIA5.

Nucleic acids research - 27 Jul 2020

An So Young, Ka Donghyun, Kim Iktae, Kim Eun-Hee, Kim Nak-Kyoon, Bae Euiyoung, Suh Jeong-Yong

Abstract excerpt

Clustered regularly interspaced short palindromic repeats (CRISPRs) and CRISPR-associated (Cas) proteins provide adaptive immunity to prokaryotes against invading phages and plasmids. As a countermeasure, phages have evolved anti-CRISPR (Acr) proteins that neutralize the CRISPR immunity. AcrIIA5, isolated from a virulent phage of Streptococcus thermophilus, strongly inhibits diverse Cas9 homologs, but the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32544231
DOI: 10.1093/nar/gkaa512
PMCID: PMC7367191

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