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Article

Potent CRISPR-Cas9 inhibitors from <i>Staphylococcus</i> genomes

2019-10-09

Abstract excerpt

Anti-CRISPRs (Acrs) are small proteins that inhibit the RNA-guided DNA targeting activity of CRISPR-Cas enzymes. Encoded by bacteriophage and phage-derived bacterial genes, Acrs prevent CRISPR-mediated inhibition of phage infection and can also block CRISPR-Cas-mediated genome editing in eukaryotic cells. To identify Acrs capable of inhibiting Staphylococcus aureus Cas9 (SauCas9), an alternative to the most commo...

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Literature Corpus work
3c42a86e-8909-5df1-9b22-13c9f3853898
DOI
10.1101/799403
Open publication

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