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Deep Learning Pathomics Integrated with Single-Cell Transcriptomics Reveals MGAT4A-Mediated "Lock-and-Load" Dysfunction of CD8+ Tissue-Resident Memory T Cells in Endometrial Cancer

2026-05-28

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<title>Abstract</title> <p>Purpose Aberrant glycosylation is a hallmark of cancer progression; however, its clinical significance in endometrial cancer (EC) histopathology and its mechanistic role in shaping the immune microenvironment remain poorly defined. This study aimed to identify glycosylation-associated pathomic features as prognostic biomarkers and to elucidate how these alterations mechanistically driv...

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Literature Corpus work
cf296540-05c1-5f58-9e67-bba019630db9
DOI
10.21203/rs.3.rs-9428731/v1
Open publication

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Deep Learning Pathomics Integrated with Single-Cell Transcriptomics Reveals MGAT4A-Mediated "Lock-and-Load" Dysfunction of CD8+ Tissue-Resident Memory T Cells in Endometrial CancerDOI 10.21203/rs.3.rs-9428731/v1
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