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Article

MGAT4A/Galectin9-Driven N-Glycosylation Aberration as a Promoting Mechanism for Poor Prognosis of Endometrial Cancer with TP53 Mutation.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 1 Dec 2024

Zhu Zhen, Sun Jingya, Xu Weiqing, Zeng Qinghe, Feng Hanyi, Zang Lijuan, He Yinyan, He Xiao, Sheng Na, Ren Xuelian, Liu Guobin, Huang He, Huang Ruimin, Yan Jun

Abstract excerpt

Emerging evidence recognizes aberrant glycosylation as the malignant characteristics of cancer cells, but little is known about glycogenes' roles in endometrial carcinoma (EC), especially the most aggressive subtype carrying TP53 mutations. Using unsupervised hierarchical clustering, an 11-glycogene cluster is identified to distinguish an EC subtype associated with frequent TP53 mutation and worse prognosis....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39527463
DOI: 10.1002/advs.202409764
PMCID: PMC11672308

Genes

MGAT4A
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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