Article

Pan-cancer Variance Decomposition Nominates Translationally Actionable Therapeutic Antigen Candidates Across 33 Cancer Types

2026-03-26

Abstract excerpt

<title>Abstract</title> <p>Computational prioritization of therapeutic antigen candidates has largely relied on mean-level differential expression, a framework insensitive to inter-patient transcriptomic heterogeneity. Here we implement a genome-wide variance decomposition engine across the full TCGA transcriptome (60,656 genes, 33 cancer types), constructing a pan-cancer antigen variance matrix from which candid...

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Literature Corpus work: 8475ffdc-740e-50c4-aef6-f3d9e06294d5
DOI: 10.21203/rs.3.rs-9215590/v1

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