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Proteogenomic insights suggest druggable pathways in endometrial carcinoma

10 Aug 2023

Abstract excerpt

We characterized a prospective endometrial carcinoma (EC) cohort containing 138 tumors and 20 enriched normal tissues using 10 different omics platforms. Targeted quantitation of two peptides can predict antigen processing and presentation machinery activity, and may inform patient selection for immunotherapy. Association analysis between MYC activity and metformin treatment in both patients and cell lines...

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PMID: 37567170
DOI: 10.1016/j.ccell.2023.07.007

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