Article

CDK12 condensation in nuclear speckles confers sensitivity to cyclin K molecular glue degraders

2025-04-01

Abstract excerpt

Transcriptional machinery often operates in the configuration of biomolecular condensates, presenting emerging opportunities to develop therapies targeting transcriptionally addicted malignancies. In this study, we discovered that cyclin-dependent kinase 12 (CDK12), a key regulator of transcription elongation, formed dynamic liquid-like droplets within nuclear speckles, a process enhanced by high CDK12 expression...

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Identifiers and source

Literature Corpus work: cf2507bd-f20a-5abd-89ba-3c0e56eb60f6
DOI: 10.1101/2025.03.31.646293

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