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Addressing Transcriptional Dysregulation in Cancer through CDK9 Inhibition

28 Feb 2023

Abstract excerpt

Undermining transcriptional addiction, the dependence of cancers on selected transcriptional programs, is critically important for addressing cancers with high unmet clinical need. Cyclin-dependent kinase 9 (CDK9) has long been considered an actionable therapeutic target for modulating transcription in many diseases. This appeal is due to its role in coordinating the biochemical events that regulate RNA...

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PMID: 36854448
DOI: 10.1021/acs.biochem.2c00609

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