Article
Current progress and novel strategies that target CDK12 for drug discovery.
European journal of medicinal chemistry - 5 Oct 2022
Lei Peng, Zhang Jifa, Liao Peiyu, Ren Changyu, Wang Jiaxing, Wang Yuxi
Abstract excerpt
CDK12 is a cyclin-dependent kinase that plays critical roles in DNA replication, transcription, mRNA splicing, and DNA damage repair. CDK12 genomic changes, including mutation, amplification, deletion, and fusion, lead to various cancers, such as colorectal cancer, gastric cancer, and ovarian cancer. An increasing number of CDK12 inhibitors have been reported since CDK12 was identified as a biomarker and cancer...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.