Article

Glycosylated clusterin species facilitate Aβ toxicity in human neurons

2022-03-25

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>Clusterin (<italic>CLU</italic>) is one of the most significant genetic risk factors for late onset Alzheimer’s disease. However, the mechanisms by which CLU contributes to AD development and pathogenesis remain unclear. Numerous studies have demonstrated that <italic>CLU</italic>-AD mutations and amyloid-β (Aβ) treatment alter the trafficking and localisation o...

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Literature Corpus work: cf194d91-1413-5fcf-b196-3e88e6b99d64
DOI: 10.21203/rs.3.rs-1439113/v1

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