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Article

Reduced secreted clusterin as a mechanism for Alzheimer-associated CLU mutations

15 Jul 2015

Abstract excerpt

BACKGROUND: The clusterin (CLU) gene has been identified as an important risk locus for Alzheimer's disease (AD). Although the actual risk-increasing polymorphisms at this locus remain to be identified, we previously observed an increased frequency of rare non-synonymous mutations and small insertion-deletions of CLU in AD patients, which specifically clustered in the β-chain domain of CLU. Nonetheless the...

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PMID: 26179372
DOI: 10.1186/s13024-015-0024-9

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