Article

Multilayered N-glycoproteomics reveals impaired N-glycosylation promoting Alzheimer’s disease

2019-04-22

Abstract excerpt

<h4>ABSTRACT</h4> Alzheimer’s disease (AD) is one of the most common neurodegenerative diseases that currently lacks clear pathogenesis and effective treatment. Protein glycosylation is ubiquitous in brain tissue and site-specific analysis of N-glycoproteome, which is technically challenging, can advance our understanding of the glycoproteins’ role in AD. In this study, we profiled the multilayered variations in...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f3117da0-c44c-535c-b410-423e4daddf74
DOI: 10.1101/615989

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Multilayered N-glycoproteomics reveals impaired N-glycosylation promoting Alzheimer’s diseaseDOI 10.1101/615989Read

Integrative glycoproteomics reveals protein N-glycosylation aberrations and glycoproteomic network alterations in Alzheimer’s diseaseSemantic proximity Read

Human brain glycoform co-regulation network and glycan modification alterations in Alzheimer’s diseaseSemantic proximity Read

Early Stage Glycosylation Biomarkers in Alzheimer’s DiseaseSemantic proximity Read

Transcriptomic and glycomic analyses highlight pathway-specific glycosylation alterations unique to Alzheimer’s diseaseSemantic proximity Read

Serum N-Glycan Profiling Identifies Candidate Glycan Biomarkers for Early Detection and Prediction of Alzheimer’s DiseaseSemantic proximity Read

Implications of Glycosylation in Alzheimer’s DiseaseSemantic proximity Read

Dessert or Poison? The Roles of Glycosylation in Alzheimer's, Parkinson's, Huntington's Disease, and Amyotrophic Lateral SclerosisSemantic proximity Read

Integrated Systems Analysis Deciphers Transcriptome and Glycoproteome Links in Alzheimer’s DiseaseSemantic proximity Read

CSF N-glycoproteomics for early diagnosis in Alzheimer's diseaseSemantic proximity Read

Unique N-glycosylation signatures in Aβ oligomer- and lipopolysaccharide-activated human iPSC-derived microgliaSemantic proximity Read

Blood N-glycomics reveals individuals at risk for cognitive decline and Alzheimer’s diseaseSemantic proximity Read

Glycosylation and behavioral symptoms in neurological disordersSemantic proximity Read