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Article

Presenilin 2 mutations alter cystatin C trafficking in mouse primary neurons.

Neurobiology of aging - 1 Mar 2007

Ghidoni Roberta, Benussi Luisa, Paterlini Anna, Missale Cristina, Usardi Alessia, Rossi Rossana, Barbiero Laura, Spano Pierfranco, Binetti Giuliano

Abstract excerpt

Mutations in the presenilin genes account for the majority of familial Alzheimer disease (FAD) cases. In the present report we demonstrated that the FAD-linked presenilin 2 mutations (PS2 M239I and T122R) alter cystatin C trafficking in mouse primary neurons reducing secretion of its glycosylated...

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PMID: 16545890
DOI: 10.1016/j.neurobiolaging.2006.01.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16545890-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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