Article

Patient induced pluripotent stem cell-derived hepatostellate organoids establish a basis for liver pathologies in telomeropathies

2021-11-20

Abstract excerpt

Patients with dyskeratosis congenita (DC) and related telomeropathies resulting from premature telomere dysfunction suffer from multi-organ failure. In the liver, DC patients present with nodular hyperplasia, steatosis, inflammation, and cirrhosis. We model DC liver pathologies using isogenic human induced pluripotent stem (iPS) cells harboring a causal DC mutation in DKC1 , or a clustered regularly interspaced s...

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Literature Corpus work: cf151f5a-cdc9-5513-ba51-8abcfa231796
DOI: 10.1101/2021.11.19.469258

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