Article

A Human Multi-Lineage Hepatic Organoid Model for Liver Fibrosis

2020-09-02

Abstract excerpt

<h4>Background</h4> To characterize fibrogenic mechanisms, genome engineering and a human hepatic organoid system was used to produce an in vitro model for human liver fibrosis. <h4>Methods and results</h4> Human hepatic organoids that were engineered to express the most common causative mutation for Autosomal Recessive Polycystic Kidney Disease (ARPKD) developed the key features of ARPKD liver pathology (abno...

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Literature Corpus work: 5b381b94-18df-5698-8642-e2c0989c0221
DOI: 10.1101/2020.09.01.278473

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